Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
quote by Francis Crick
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
quote by Francis Crick
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The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority.
quote by Francis Crick
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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
quote by Francis Crick
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
quote by Francis Crick
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It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.
quote by Francis Crick
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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
quote by Francis Crick
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
quote by Francis Crick
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
quote by Francis Crick
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That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.
quote by Edward Lawrie Tatum
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Mathematics is the most powerful tool that people have developed to investigate the world around us. But it is taught so that students do not realize this. The language of mathematics is able to describe objects, structures, properties and relationships in an unambiguous way. In this context we talk about the power of the "descriptive" of mathematics. In this way, people were able to formulate and express such assertions accurate and unambiguous knowledge.
quote by Juraj Hromkovic, translated by Marin Vlada
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The mute Lady
A demure lady was near my sight.
I could not sleep, try as I might.
I was beset; my heart in a glow.
I sent out my measured look, saw
Her unobtrusive, serene face
Cast down at work in phase.
Cognizant of me though she is,
She refused to court my eyes.
Her triplet: modesty, reticence,
And timidity coalesced to the incense,
That drove me out of sense,
My passion for her lurking tense.
Never rested my perverse look,
However resolute she might prove.
Her triplet by its nearness was my plight.
I could not retreat, try as I might.
I am tired; have I to retire?
Mute Lady, the care can you spare?
Why should your triplet me only excite
And leave others from the orbit?
Flinch not. My ingenious act,
I could not resist, try as I might.
Why should your aura assail my soul
What no one else but I can feel?
You’re not mute, subliminally hot,
Mute Lady, my acumen can spot.
12.11.2000, Pmdi
poem by Rm. Shanmugam Chettiar
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Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
quote by Francis Crick
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Well, I - all cases to me have interest. Every case is important to somebody, the people litigating that case. But the most difficult case for me is the case where one person says a, the other person says b, and you just don't know for certain who is not telling you the truth.
quote by Judge Mills Lane
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Just trying to get a film made which is always difficult no matter what kind of a budget you have. Not having a budget makes it even more difficult. Having nineteen days and no budget makes it extremely difficult.
quote by Eriq La Salle
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There are many methods for predicting the future. For example, you can read horoscopes, tea leaves, tarot cards, or crystal balls. Collectively, these methods are known as 'nutty methods.' Or you can put well-researched facts into sophisticated computer models, more commonly referred to as a complete waste of time.
quote by Scott Adams
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Without ambition one starts nothing. Without work one finishes nothing. The prize will not be sent to you. You have to win it. The man who knows how will always have a job. The man who also knows why will always be his boss. As to methods there may be a million and then some, but principles are few. The man who grasps principles can successfully select his own methods. The man who tries methods, ignoring principles, is sure to have trouble.
There are many methods for predicting the future. For example, you can read horoscopes, tea leaves, tarot cards, or crystal balls. Collectively, these methods are known as "nutty methods." Or you can put well-researched facts into sophisticated computer models, more commonly referred to as "a complete waste of time."
Scott Adams in The Dilbert Future
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Hard Up Case
You told me once I was your pride and joy
I guess those days are dead and gone
You must have took me for some golden boy
You didnt know what you were taking on
It was a hard up case
It was a hard up case
Just another hard up case
It was a hard up case
Just another hard up case
Now all the angles have been played in threes
There isnt much that I can say
I know you gave your little heart to me
I guess I threw the thing away
It was a hard up case
It was a hard up case
Just another hard up case
It was a hard up case
Just another hard up case
Sometimes the truth is kind of hard to find
But dont you worry I can read your mind
And you dont have to tell me to my face
You put some other joker in my place
They dealt us houses full with the queens and kings
And now theyre calling out our bluff
cause you and me girl we had everything
But it just wasnt quite enough
Now thats a hard up case
It was a hard up case
Just another hard up case
It was a hard up case
Just another hard up case
You say the truth is gonna set me free
Like you might throw a dog a bone
I know youre thinking that the jokes on me
Just take a look at what you re dragging home --
Another hard up case
It was a hard up case
Just another hard up case
It was a hard up case
Just another hard up case
song performed by by Steely Dan
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Triplets
Depending on your point of view,
If you think they're first rate,
We know what lion cubs can do,
But triplets can be great!
Yes, lion cubs are little tykes!
Three rascals can be fun...
With each cub doing as he likes,
Till he sleeps in the sun...
They're nodding off... plum tuckered out...
Yet they don't want to snooze!
They'd rather pounce and jump about,
With cunning, cruise and bruise...
They'd rather scratch and bite and roar,
Cause chaos for a while...
Than simply, merely, humbly snore...
And lose all sense of style.
The other cubs aren't tired yet,
They slowly bide their time...
For some revenge they'll swiftly get
And won't that feel sublime?
The triplets haven't got a prayer!
They've got to go to sleep!
The other cubs are well aware...
As they, their vigil, keep!
Denis Martindale, copyright, November 2010.
The poem is based on the magnificent painting
by Stephen Gayford called 'Triplets'.
More Stephen Gayford poems here:
denis-martindale-dot-blogspot-dot-com
poem by Denis Martindale
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My Country
Was it just a dream, were you so confused
Was it just a giant leap of logic
Was it the time of year, that makes a state of fear
Methods were the motives for the action
And did I hear you say
My country right or wrong
Did you save your face
Did you breach your faith
Women, there were children at the shelter
Now who can stop the hail
When human senses fail
There was never any warning, no escape
Did I hear you say
My country right or wrong
My country oh so strong
My country going wrong
My country right or wrong
I hear you say the truth must take a beating
The flag a camouflage for your deceiving
I know, yes I know
Its written on your soul
I know, we all make mistakes
This is not a case of blurred vision
Its a case of black holes, pocket holes, soul holes
And did I hear you say...
(hirst)
song performed by by Midnight Oil
Submitted by Lucian Velea
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