Inborn Errors of Metabolism (IEM)

God made the earth perfect for man,
With all comforts throughout life-span;
Man's activities change the earth,
Affecting life, even at birth!

When genes defective turn in womb,
And enzymes, proteins fail to form,
A host of symptoms, signs take on
The child, as soon as it is born!

Gone are some genes somewhat astray!
Enzymes, proteins can't form right way;
This change in gene does truly stay,
And life isn't normal any day!

Defects in genes block met-pathways -
Substrates to products held at bay;
Through autosomes, recessive way,
Or X-linked, genes forever stay!

Intra-natal screenings detect;
Treatment today is imperfect;
Avoid the protein, its effect:
Future outcomes, good hope inject!

Enzyme replacement, gene transfers,
Food supplements, dialysis,
Transplanting organs, bone-marrow -
Could make life better tomorrow!

Garrod brought diseases to light,
With Alkaptonuria's insight!
But continue will mankind's fight,
With scientific research and might!

Dedicated to all scientists, doctors, clinicians and students,
who toil to make the world disease-free!

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Sonnet- Genes Matter But…

No longer secret's the genome of man!
The gene make-up of all beasts will be known;
Man's actions and misdeeds, alter none can,
Except man himself, using his mind own.

How can the new knowledge of genes prevent
The growing crimes against men in this world?
For his grave sins unless man can repent,
He will suffer in hell or when he's old.

The society's problems, man must resolve,
Thro' self-control and love of his neighbour;
By brotherhood of nations, man can solve,
Most of the problems and make earth better.
Knowing one's genes is not the solution;
Know thine own mind by self-realization.

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Sonnet: Genes Matter But…

No longer secret's the genome of man!
The gene make-up of all beasts will be known;
Man's actions and misdeeds, alter none can,
Except man himself, using his mind own.

How can the new knowledge of genes prevent
the growing crimes against men in this world?
For his grave sins unless man can repent,
He will suffer in hell or when he's old.

The society's problems, man must resolve,
Thro' self-control and love of his neighbour;
By brotherhood of nations, man can solve,
Most of the problems and make earth better.
Knowing one's genes is not the solution;
Know thine own mind by self-realization.
Copyright Dr John Celes

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Bloodline Of My Children

He out those genes into the bloodline and,
Of the woman that gave birth to his children;
But every one is judged for what they do on this earth.

The inner garment is what you need,
And with the discomfort acts during the time of trouble;
But the nuclear fires will comsume the earth.

I want to know what is in your heart and,
What you deserve from me;
For the worth of my love is what you need,
Because my genes will be needed in the bloodline of my children!

Will you go to Yahweh Shammah with me? !
For there is the truth and you will become my lover! !
And the miracles around will come into your muse,
But the recorded history is here to guide us.

Rejoice and see the day of brightness with me,
And just like the others who lived long ago;
For the desire of this muse had made things possible,
And i was born just like you by a woman.

I don't need man-made laws over here,
For te love is you is very spiritual to my heart!
And just like those genes in your bloodline.

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Where are the intelligent people?

I agree with everyone that we are over populated,
Because we have our genetic pool intact,
We have never believed in the Eugenic Movement,
that promoted the selective breeding in human,
Thousands of human were sterilized in Europe,
For they had the low IQ, as if the IQ is genetic,
Millions of men and women were slaughtered in the wars,
As the dictators trusted the inferior genes in holocaust,
Human are manipulated to live the life of single,
In the name of the son and his cross and struggle,
If the men are clever, Catholics force them to be the priests,
If a girl is beautiful and intelligent, she is sent to nunnery,
The good genes of Europeans are lost in their beliefs,
The good genes of Europeans are lost in their misbehavior,
They need the people, who have good genes in their brains,
To do the programming and to run their everyday life,
We run for it leaving our loved ones behind,
We are the coolies in their land, still proud to say that.

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What does gene A do? What does gene B do? What does it do in different contexts? What's its importance? We know the answer to that for a very small number of genes, the ones that made themselves evident many years ago.

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From These Genes

It is from these genes,
From which the genius beems.
It seems to create delicious dreams.
Like the juice that flows to taste familiar...
Yet so sweet.
It's too much to keep it hidden.
Or fabricate its comfort.

It's from the planted seed that's nourished.
To grow, bloom and rejoice the moment!
And it's good...
When it is seen that way!
And better when it isn't.

It is from these genes,
Within me to encourage...
Self,
With a desire to grow.
And to know what I can...
Or can not do.
If I just go ahead and do it!
To prove it to myself.

It is from these genes...
That I have taken so much for granted!

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By then, I was making the slow transition from classical biochemistry to molecular biology and becoming increasingly preoccupied with how genes act and how proteins are made.

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And of course, identifying all human genes and proteins will have great medical significance.

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So no, it's not all in the genes, but what isn't in the genes isn't in the family environment either. It can't be explained in terms of the overall personalities or the child-rearing practices of parents.

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Here Comes Frankenstein

Climb the faded tower and see
They spliced the genes of fish with tomatoes
They want the tomatoes to look fresh
Supreme Court rules on the side of industry
Intellectual property over nature
They let corporation’s patent life
They are changing species
Creating dominant strains
They can copyright genetically modified products
Clarence Thomas was a Monsanto lawyer
Five too four rulings again and again
Biotechnology runs rampant
Gene splicing on a world level
Coca Cola wants fresh water
They go into poor countries and ruin them
The World Bank supports cash crops
Only one percent of the population benefit
Stockholders and the super rich, real wages decline
Pharmaceutical industry drugs everyone
Globalize the world into corporate fences

Species decline, rain forests cut
Huge parks support lions, tigers
Everything becomes preserves and zoos
Everything is looked at like commodities
They have spliced spider genes with goats
They want the strong spider thread
Who gives them the right?
So little political will
Salmon farms with treated fish
Cows that no longer graze and eat corn
Industry changing life patterns
Massive cruelty to animals
Pigs are smarter than dogs
Many never graze and some don’t even stand
Chickens with broken legs because of growth hormones
Never even seeing sunlight
Pumped up with hormones like they are not alive
These animals are pumped with antibiotics
They live and die unhealthy
All for profit and we say nothing

They are going to change man
They tamper where they do not belong
They say the evil is over in Pakistan
Look and see the evil all around
Look and see how our food is controlled
See all the genetically modified products
They don’t even tell us how far they have gone
Science in the hands of money and profit
Mixing species until they will create a genetic disease
More and more bionic organs
More and more artificial intelligence mixed with bionics
They will develop brain chips and sell genes and organs
They will mix man with other species
No God, no ethics only profit, patents and control
Knowledge in the hands of Dracula
CEO’s making a thousand times more then a worker
Billionaires and beggars
We have come along way haven’t we?
1984 and Brave New World
A new age of biotechnology in the hands of conglomerates
Man over man produces a strange new man

Frankenstein is on its way

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Fighting hard to protect yourself and your relatives is good for your genes, but when captured and escape is not possible, giving up short of dying and making the best you can of the new situation is also good for your genes.

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Scientists have found the gene for shyness. They would have found it years ago, but it was hiding behind a couple of other genes.

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God’s Gifts to Man

One finger gone can make one look ugly;
One missing leg can make life so dreary;
One scar on face can ruin complexion;
One eye that’s blind can make life difficult.

A fractured bone makes rest, a misery;
A heart attack turns life so miserable;
A seizure illness needs life-time of drugs;
A diabetic may need ‘insulin-pricks’!

The body-organs God-given are great;
They work with harmony and precision;
We do not know their values until late;
No pump on earth can beat like natural heart.

From dust, God made man very brilliantly;
God’s love for man is almost infinite!
Is not the human body sacrosanct?
And yet, we do not rest our body-parts!

There’s nothing like the circadian rhythm;
Each cell has machinery adequate;
The genes control all metabolic acts;
The fetus is a miniature human!

So, hygiene is so important in life;
Some discipline is essential too;
Our habits must not cause much ‘wear and tear’;
We need both quality and long life-span.

The human mind and body are assets;
There is no wealth better than these on earth;
A healthy person lives with forbearance;
Firm faith in God is foremost need of life.

Copyright by Dr John Celes 4-11-2008

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Lewis Thomas

It is from the progeny of this parent cell that we all take our looks; we still share genes around, and the resemblance of the enzymes of grasses to those of whales is in fact a family resemblance.

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My Genes

My genes have just abandoned me
And taken off my son
To far exotic places
Looking for more fun.

They never even warned me
Or said a last goodbye
They thought that they knew better
And o'er the sea did fly.

It really came as quite a shock
This infidelity
But genes care not for feelings
Or nationality.

Their loyalty is suspect
They are quite devoid of spines
To put it impolitely they're
Two-timing little swines.

I just assumed they'd stay here
At least I thought they should
I've carried them for donkeys' years
In flesh and bone and blood.

But soon they'll be Canadian
When from our Kev' they pass
(I wonder if they're thinking
That they'll then be upper-class) ?

I've thought about it quite a lot
And hope that you'll agree
That I should have them back again
But that's not up to me.

My chances of retrieval
Are as walking to the moon
So the only way to catch them
Is to go to Saskatoon.

(Written Dec 1998)

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Parents provide their children with genes as well as an environment, so the fact that talkative parents have kids with good language skills could simply mean that and that the same genes that make parents talkative make children articulate.

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Short Story of the HIV

A Retrovirus threatens man,
Whose youth dare risk their lives sometime,
By indulging in unsafe sex,
Earlier in life than expected!

The young adults affected, die
Early in life, than most others!
Their partners get the virions,
Through heterosex and homosex!

Some get the virus through blood route:
Infected blood, I V drug use;
Some mothers pass virus to babes
Through placental route, while in womb!

The virus once within body
Enter immunocytic types
And replicate within such cells,
And killing them, before they leave!

Avoid then, getting the disease;
Use condoms to make sex safer;
Be faithful to your life-partner;
Don’t share needles if drug-user!

There is no cure for this disease –
A chronic one that surely kills!
ART early can contain
The viral growth and slacken spread!

A proper vaccine is ideal,
If made without any delay;
But making it is not easy,
As virus genes can change make-up!

And victims die of infections
Opportunistic and severe;
Most suffer from Tuberculosis,
And tumors that can kill them fast!

’Tis sad to see the victim melt
To just a skeleton skin-clad;
The virus spares no one on earth
Who performs sex immorally!

Awareness has been created;
Discrimination still abates;
The infection rate is lesser;
The war on HIV goes on!

Dedicated to ‘every hero
Who aims to make AIDS, a zero! ’
By the Dean, IRT PMC,
On the occasion of the
World AIDS Day,2011
On behalf of the ‘Red Ribbon Club’
Of IRT PMC, Perundurai
Copyright by Dr John Celes 1-12-11

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Sonnet-Nature's The Best

The child with milestones normal is the best;
The child that gets parental love grows well;
The teeth that timely erupt grow, strongest;
The good man from the bad, genes, time will tell.

The fruit thats ripe on tree does taste the best;
One ripened artificially isn't that good;
The child that learns naturally performs best;
That cooked in earthenware's the tastiest food.

God -given breeze is what most men prefer;
Air-conditioned has its demerits sure;
That Natural things are best, we all infer;
For Man is too a part of God's Nature.

Respect Nature and Earth will remain green;
And keep soul pure when life will be serene.

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Beloved Parasite

Within the womb two strains combine.
Some genes of your with genes of mine.
To form a brand new entity.
Which thrives in the security.

Divides and sub divides again
develops limbs, organs and brain.
All of its needs mother supplies
A veritable paradise.

Takes what it needs quite selfishly
existing parasitically
Its only purpose is to grow.
That’s all it knows or needs to know.

But mother knows the time will come
when he must leave his present home
and face the hostile world outside.
Her hopes and dreams well satisfied

Although the baby will
and seek the comfort of her breast.
There is no choice it has to be
an independent entity.

No longer just a parasite.
The baby still retains the right.
To have its wants and need supplied
which mother’s readily provide.

A petty tyrant who demands
obedience to his commands.
A whimper brings her to his side
His wishes must be satisfied.

10-Sep-08
http: // blog.myspace.com/poeticpiers

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Sonnet: God’s Special Love

The love of God had given us our form
Wholesome and perfect, while in mother’s womb;
The environs then tried to us deform:
Some ending without being born in tomb!

The love of God had given parents good,
Who reared us with great care to adulthood;
And taught us basic things we need in life,
And how to toil and overcome our strife.

The love of God had given us life-span-
Our precious time on earth to work for Him;
The Hand of God protected each human,
From foes, travail and when life became grim.

God’s special love chose us before our birth,
For being born, human being on earth.

Copyright by Dr John Celes 3-2-2008

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